RNA interference
Now well documented in mammals, RNAi appears to regulate gene expression post-transcriptionally via an evolutionarily conserved pathway involving highly coordinated RNA-protein interactions.
The use of synthetic, small interfering RNAs (siRNAs) introduced into cells circumvents this response, allowing targeted, gene-specific suppression without induction of global, non-specific cell death.
Includes:
Application in target validation
Potential for therapeutic development